Albinism Essays (1256 words) - Skin Pigmentation, Albinism, Melanin

Albinism Essays (1256 words) - Skin Pigmentation, Albinism, Melanin Albinism INTRODUCTION For my research project I have chosen the genetic disease albinism. There are a few reasons why I chose albinism as my topic. First and foremost, in kindergarten I had a friend who was an albino, and although I have not seen him in over 10 years I am still curious as to what the causes of albinism are. Back then, my mother explained it to me by saying, thats just the way his skin is which is a fine way to explain it to a five year old, but now I find myself wanting to know more. Another reason I am curious about albinism actually extends from my first reason. I often wondered if there was any chance that my kids could possibly be born with it. I know now that it sounds a little bit ridiculous but I would sometimes worry that I wouldnt be able to take my children to the beach (I knew this because my friend from kindergarten could never come with us when we went in the summer). I also used to wonder whether or not my friend could see the same way I could, since his eyes looked so different from mine. As a result of all of this, I could not turn down the opportunity to research a disease that has held my curiosity for such a long time. PHENOTYPIC CHARACTERISTICS The most prominent phenotypic characteristic of albinism is obviously the lack of skin coloring. Albino skin is whitish in appearance, sometimes seeming to be almost translucent. Similarly, albino hair is also very pale, appearing closer to white than blonde. Albinism makes the skin extremely sensitive to sunlight. Albinos need to be very careful about exposure to the sun as they have a very high risk of burning due to lack of protection from ultraviolet rays, which is normally provided by the pigment melanin (2). Similar to the skin, albino eyes also lack color; the irises usually appear pinkish. People with albinism often have eye problems. First of all, they suffer from severe sensitivity to bright lights. Cases of extreme nearsightedness or farsightedness that cannot be completely corrected with eyeglasses are also common. People with albinism also sometimes demonstrate an involuntary back and forth movement of the eyes called nystagmus. Finally, people with albinism are more likely to develop astigmatism. It is possible to have albinism that affects the eyes without also affecting the skin. This is known as ocular albinism (3). INHERITANCE Albinism is an autosomal recessive disorder. All the children of two affected homozygous affected parents are also affected. This means that two parents who have albinism, and who possess two recessive alleles each for albinism will produce affected children 100% of the time. Being a relatively rare disorder, albinos are often the children of unaffected parents (this is the case with autosomal recessive disorders). Parents who are both heterozygotes (both carriers of the disease but not having it themselves) have a 75% chance of producing a normal, non-affected child. Because albinism is not carried on the sex chromosomes, it is expressed equally in both males and females, and either parent can transmit the disorder. Albinism also affects people of all races equally. Approximately 1 in 17,000 people has one of the types of albinism, which amounts to roughly 18,000 people in the United States (1). GENETIC AND CELLULAR ORIGINS Albinism is located on chromosome 11q 14-21. The gene associated with albinism is called OCA1 (among a few others). OCA1 codes for the protein tyrosinase. This protein is responsible for converting tyrosine into something called DOPA (dihydroxyphenylalanine). DOPA plays an important part in the formation of melanin by next becoming dopaquinone. Dopaquinone then forms black-brown eumelanin or red-yellow pheomelanin. Melanin is a pigment, the absence of which causes albinism (2). Albinism occurs when something causes the OCA1 gene to function improperly. This improper function disrupts the production of tyrosinase. With tyrosinase production malfunctioning, it is impossible for the body to make DOPA and as a result the body is also prevented from making melanin. The absence of melanin causes the lack of color in the skin of people who are affected with albinism (2). MOLECULAR ORIGINS The cDNA sequence for the OCA1 gene is 1607 bases long; 325 Adenine,

Free Online Classes for West Virginia K-12 Students

Free Online Classes for West Virginia K-12 Students West Virginia offers resident students the opportunity to take online public school courses for free. Below is a list of no-cost online schools currently serving elementary and high school students in West Virginia. In order to qualify for the list, schools must meet the following qualifications: classes must be available completely online, they must offer services to state residents, and they must be funded by the government. Virtual schools listed may be charter schools, state-wide public programs, or private programs that receive government funding. List of West Virginia Online Charter Schools and Online Public Schools West Virginia Virtual School Online Charter Schools and Online Public Schools Many states now offer tuition-free online schools for resident students under a certain age (often 21). Most virtual schools are charter schools; they receive government funding and are run by a private organization. Online charter schools are subject to fewer restrictions than traditional schools. However, they are reviewed regularly and must continue to meet state standards. Some states also offer their own online public schools. These virtual programs generally operate from a state office or a school district. State-wide public school programs vary. Some online public schools offer a limited number of remedial or advanced courses not available in brick-and-mortar public school campuses. Others offer full online diploma programs. A few states choose to fund â€Å"seats† for students in private online schools. The number of available seats may be limited and students are usually asked to apply through their public school guidance counselor. Choosing a West Virginia Online Public School When choosing an online public school, look for an established program that is regionally accredited and has a track record of success. Be wary of new schools that are disorganized, are unaccredited, or have been the subject of public scrutiny. Evaluating virtual schools is important to ensure that it meets the students needs and fulfills educational requirements.

Financial accounting Assignment Example | Topics and Well Written Essays - 1000 words - 1

Financial accounting - Assignment Example In addition, through integrity, external auditors are required to avoid conflicts of interest when making their reports. In this way, their judgment will be imperative to the shareholders, directors, banks and other users of the audited reports. Question 2 One of the major factors to consider before investing in the biotechnology company is the profitability of the company. Through the audited financial reports, an investor will note the amount of profits and divided paid to the shareholders. In this way, an investor is at a good position to make an appropriate decision before investing in the company. Secondly, an investor should know the sources of finance adopted by the company. Companies that have wide range of sources of finance have a higher probability to survive in the current competitive business arena. Similarly, through various sources of finance, the concept of business as a going on concern is guaranteed since the company is financially stable. Another vital aspect that as an investor I will need to know is the management of the company. If the company has a strong management and auditing team and policies, it implies that financial position of the company is good thus guaranteeing high returns to the shareholders. Likewise, it is fundamental to have adequate information on the strategic plans of the company. For instance, if the company is focused at being acquired by another major company, it may result to an expansion of its services thus generating more returns. On the other hand, a company with unclear plans may fail in future thus making it unviable to invest in. Question 3 One of the recent major accounting scandals is the one that involved Olympus, a Japanese based firm that specializes in the production and selling of medical equipments and cameras. According to New York based prosecutors, Chan Ming Fon, one of the company executives was engaged in covering more than $1.7 billion losses thus providing false information to the auditors. The funds that were illegally acquired by the executives together with other seven employees were transferred to unknown financial institutions through the wire transfer. According to the FBI, Chan notified the auditors that the company funds were held in the form of Japanese bonds while in the real sense they were used to repay a loan through a firm that was under the control of Olympus. The whistle blower of this scandal was Michael Woodford soon after he was fired as British CEO in 2011. To prevent such a scandal, I suggest that auditors would seek more details and prove of all the information provided by the company. It would be also imperative for the government to intervene by bringing on board external auditors at the initial stages when the fraud was detected. Question 4 Taking into consideration that accrual accounting matches the revenue generated with the expenses incurred within a specific period of time, I would first take the bank statements that depicts the cash collecti on and payments for the first six months the period that my clients want to be audited. In the same way, I would separate the invoices and the bills that are covered in the first six months. This will be followed by comparing whether the sales incurred in the first six months are inline with the expenses incurred within the same period. According to accrual accounting, selling products on credit may result to future revenue streams that may affect the current financial position of the company (Barry and Jamie 11). To avoid this scenario, I would treat all the credit sales within the first six months as account receivables. For example, computers that were repaired

Strategic Assessment of Wal-Mart for an ITM class Essay

Strategic Assessment of Wal-Mart for an ITM class - Essay Example Many others are of the view that the current problems were because of Wal-Mart’s failure to incorporate state-of-the-art IS/IT technologies in its operations. Being a business technology consultant hired by Wal-Mart, I do believe that Wal-Mart is in trouble mainly because of its failure to incorporate suitable IS/IT technologies in its activities. Offline businesses are currently giving way for online businesses or e-commerce. It is important for Wal-Mart to give more attention to online businesses. â€Å"Wal-Mart has assembled a team of 70 developers, computer engineers and researchers — dubbed @WalmartLabs — in an aggressive attempt to position itself at the forefront of social and mobile commerce† (Wal-Mart: The Next Tech Giant?). However, its e-commerce platform still needs more fine tuning to attract more visitors. Just like Amazon and Google, it is better for Wal-Mart to enter into the search engine business so that it can expand its business portfolios as well as enhance its retail business. Shopperception is a new IT related technology evolved out in recent times to check the consumer behaviours and buying habits. â€Å"Shopperception recognizes the customers when they check-in and it remembers previous buying habits and can predict what the customer is likely to want on this visit† (Israel). Wal-Mart should use this technology extensively in its retail outlets to help the consumers. â€Å"The Wal-Mart network, connecting more than 2,400 stores and 100 distribution centers worldwide. At Wal-Mart, we dont implement technology for its own sake," says David Flanagin, Director of Network Engineering† (The Wal-Mart Story, p.1). From the words of David, it is evident that Wal-Mart is not much keen in using technologies to improve the efficiency of its global activities. It should be noted that efficient working of a supply chain is necessary for Wal-Mart to

Black People and Prejudice Essay Example for Free

Black People and Prejudice Essay â€Å"Ahhhhhhhh!† I squealed and jumped for joy the moment I dropped the phone. I hurrily scurried over to my mom to share the news. â€Å"Mommy, I got my first job!† This was the stepping stone to me being an independent young woman. I was officially employed at Hollister Co. as a sales model. I was ecstatic and excited to make some money at the tender age of 15. My first week was definitely a learning experience; from learning how to maintain a cash registrar to folding tons of polos and jeans. Soon through this journey, it started to become bittersweet. With three months of being employed, my shifts were diminishing from 4 shifts a week to 1 shift a week. As I looked at the schedule postings for the week, I noticed a trend with the scheduling of the shifts. Ironically, most of the employees that were working more hours and more shifts were white females. I figured it might have something to do with the fact that my supervisor is a white surfer-boy who is infatuated with beach-blonde beauties. However that did not stop me from asking him to put me on the schedule more. Sadly, I resent the day I had asked him. Unfortunately, he felt that I didn’t have the â€Å"natural beachy look† that Hollister Co. was trying to perceive. I am of Malaysian decent and have tan skin color. Hearing that definitely bruised my ego and made me self-conscious about my appearance. I felt this was a tactic for me to quit, and so I did. Over the months I begin to realize that ultimately there will be people in the world that have a perspective of life that I cannot seem to change. I had realized that this was not my fault; it was his own personal judgment that led him to think that. I was treated this way because of how I looked not on who I am. Many people have tried to explain the reasoning of why people are prejudiced and discriminate against one another. Two readings that are eye-openers about prejudice are Causes of Prejudice and C.P. Ellis. In the essay, Causes of Prejudice, the author Vincent N. Parrillo explains the reasons for racism and discrimination in the United States. Which brings us to Studs Terkel’s essay C.P. Ellis, he tells us the story of C.P. Ellis, a former Klansmen who claims he is no longer racist. With Parrillos essay, we will analyze what caused C.P. Ellis to be prejudice and how he changed. Parrillo’s Causes of Prejudice outlines reasons how and why prejudice exists in today’s society. Parrillo first starts out telling us that prejudice is the rejection of a member of a certain culture, and that ethnocentrism is a rejection of all culture as a whole. He then states that there are four areas of study to consider when dealing with prejudice; levels of prejudice, self-justification, personality, and frustration. This theory is ideal to the root of why and where prejudice starts. He explains that the first level of prejudice is the cognitive level of prejudice. This is a person’s beliefs of a culture. The second level is the emotional level of prejudice. This level includes what kind of emotional response a culture has on a person. These emotions for example can be that of hate, love, fear, etc The final level, explains Parrillo, is the action oriented level. This is the desire to physically act upon their prejudice feelings toward the person or culture. As stated in the text, â€Å"The emotional level of prejudice encompasses the feelings that a minority group arouses in an individual. Although these feelings may be based on stereotypes from the cognitive level they represent more intense stages of personal involvement† (Parrillo 386). His statement holds true. In the sense of economic competition prejudice occurs frequently. We need to realize that jealousy is an important factor of prejudice. There would still be competitions, hatred, and stereotyping. It is just in our human nature. The story of C.P Ellis begins as he discusses his life as being a white male from a low-income class. His frustrations and misfortunes lead him to become a member of the Ku Klux Klan. His father always told Ellis to stay away from blacks, Jews, and Catholics’ and he obeyed his father’s wishes. In a sense, it seemed as if Ellis truly admired his father. At 17 years old, his father soon passed away and Ellis was forced to work to tend to his family. Ellis discusses his frustrations on having to make ends meet with four children, the eldest being mentally challenged and the struggles he has to endure to make it happen. Ellis begins to blame the black people for his tragedy and his misfortune of not being able to have sufficient funds. In relevance to Parrillo’s essay, he explains that â€Å"frustrations tend to increase aggression toward others† (Parrillo 393). This ties into the anger that Ellis began to direct it towards as he stated, â€Å"I didn’t know who to blame. I tried to find somebody. I began to blame it on black people. I had to hate somebody† (Terkel 400). Ellis believed that blaming others rather than himself was the best way to get over his frustrations. We are then exploited to the self esteem Ellis had and his state of mind when starting his racist rampage. To begin with, Ellis shows throughout the essay that he is weak minded and has very low self-esteem. Ellis states, â€Å"The majority of ‘em are low income whites, people who really don’t have a part in something. They have been shut out as well as the blacksSo the natural person to hate would the black person† (Terkel 401). Ellis started to hate the fact that he was poor and turned to the KKK. He felt the KKK opened opportunities he could achieve because of the stability and members of the group. Parrillo states that â€Å"self-justification† is lead to believe the main cause of prejudice. He states â€Å"a person may avoid social contact with groups deemed inferior and associate only with those identified as being of high status† (Parrillo 387). We can identify the behaviors and personality Ellis displays is relevant to the same behaviors and personality of his father. Throughout the story, Ellis directed his hatred towards blacks just like his father did. Ellis states â€Å"The natural person for me to hate would be black people, because my father before me was a member of the Klan. As far as he was concerned, it was the savior of the white people† (Terkel 400). We can recognize that his racist ways came from his father who told him what to believe. We can identify this as the â€Å"socialization† factor of prejudice. When one is taught something which they live by all their life they begin to play a role just as the one who taught them those ways. Parrillo elaborates, â€Å"We thus learn the prejudices of our parents and others, which then become part of our values and beliefs. Even when based on false stereotypes, prejudices shape our perceptions of various peoples and influence our attitudes and actions toward particular groups† (Parrillo 394). We can make the connection that Ellis’s father was racist he gained his father’s characteristics as well as his beliefs. This also ties in when he begins to blame black people because he was taught they were the cause of the economic problems he was facing. Ellis states â€Å"If we didn’t have niggers in the schools, we wouldn’t have the problems we got today† (Terkel 402). Here he did not truly experience what he believed but he was told this and began to live by it, which was passed down by his father. Over the time, Ellis and his views about the blacks changed altogether. In the end, Ellis has an epiphany once he realized how much in common he really had with blacks. He soon began to realize that black people were just as normal and looking for the same thing in life. He tells us what he realized later in his life â€Å"As long as they kept low-income whites and low-income blacks fightin’, they’re gonna maintain control† (Terkel 403). The revelation is going to change his life. He refers to they as being the politicians and government. He began to have his own mind set and realize that all are alike and should not be treated differently. Some white people had just as low incomes as some black people, which led him to realize that they were all at the same level. There is no explanation as to why Ellis really decided to all of a sudden change his views. We can relate this to Parrillo’s statement, â€Å"Although socialization explains how prejudicial attitudes may be transmitted from one generation to the next, it does not explain their origin or why they intensify or diminish over the years† (Terkel 394). In conclusion, both Parrillo’s essay and Ellis’s story go hand in hand in showing us the real reason why prejudice and racism still exists today. Vincent Parrillo exemplifies valid points and key notions on why cause a person to be prejudice and racist. C.P Ellis provides an insightful eye and truly gives us hope that maybe people will change their views over the years. Both showed us that prejudice is a prime factor in this society and this is because everyone was born and raised differently. Everyone has their own beliefs and ideas. Value, attitudes, beliefs and culture all are targets of prejudice. Regardless of anything, we will never be able to change that. People just try to persevere to the stereotyping and criticizing of other races and their own. Works Cited Parrillo, Vincent N. â€Å"‘Causes of Prejudice.† Rereading America: Cultural Contexts for Critical Thinking and Writing. Ed. Gary Colombo, Robert Cullen, and Bonnie Lisle. 8th ed. Boston: Bedford St. Martin’s, 2010. 384-398. Terkel, Studs. â€Å"C.P Ellis.† Rereading America: Cultural Contexts for Critical Thinking and Writing. Ed. Gary Colombo, Robert Cullen, and Bonnie Lisle. 8th ed. Boston: Bedford St. Martin’s, 2010. 398-408. Self-Editing Checklist: 1. Do you have a sufficient number of quoted passages from theoretical essay you have chosen and have you commented sufficiently on each? List the page numbers of the passages below. Page 386 Page 387 Page 393 Page 394 2. Do you have a sufficient number of quoted passages from personal essay you have chosen and have you commented sufficiently on each? List the page numbers of the passages below. Page 400 Page 401 Page 402 Page 403 3. Explain the order in which you chose to make your points via the passages you quoted. Studs Terkel then Vincent Parrillo ⠝â€" Page 386 ⠝â€" Page 393 ⠝â€" Page 400 ⠝â€" Page 401 ⠝â€" Page 387 ⠝â€" Page 400 ⠝â€" Page 394 ⠝â€" Page 402 ⠝â€" Page 403 ⠝â€" Page 394 4. Name three writing errors you are likely to make in your prose and check the rough draft for these. Use the OWL website if necessary to look for examples of how to address these problems. List the likely errors below. Alternating long and short sentences. 5. Read your final draft of the essay aloud so that you do not allow your eyes you’re your brain to self-correct the errors in your essay. List the kinds of errors you found below. Spelling, grammar, punctuation.

Supporting Womens Empowerment Essay -- essays research papers

Abstract Women empowerment is much talked about an issue by academicians, political thinkers and social scientists as regards to concepts like gender equality, financial independence, social inclusion, power etc. However there is a dire need of conceptual clarity of the term empowerment. This can be done by delineating it with the above overlapping concepts and suggesting inclusive approach towards enabling women themselves to critically review their own situation and participate in creating and shaping the society as agents of change themselves. Women themselves need to define the term empowerment which cannot be defined in terms of specific activities or end results because it involves a process whereby women can freely analyze, develop and voice their needs and interests, without them being pre-defined, or imposed from above. Masculinity Equality and Women?s Empowerment: There could be statistical evidence indicating improvements in indicators of gender equality, but unless the intervening process involved women as agents of that change, one cannot term it as empowerment. Gender equality or equity indicates the degree of equivalence in life outcomes for women and men, recognizing their different needs and interests and requiring a redistribution of power and resources. The women needs to build the conceptual framework of power for her and only then the concept of women empowerment and equality would hold relevance. This paper conceptualizes the issues of women empowerment through making her an agent of change for her own equivalence and studying the various domains where empowerment can be applied and discussed. 1. Economic participation 2. Economic opportunity 3. Political empowerment 4. Educational attainment .. ...olitical participation, and with relatively equal educational and economic opportunity and participation. Yet, as this study indicates, other countries show wide variation, lagging far behind in particular areas, some across all five dimensions. Aside from this general conclusion, and broad country comparisons, the data we have presented here shed light on the disparities within countries, in some cases either confirming formation gathered in other ways, or, in others, countering prevailing assumptions. By identifying and quantifying the gender gap, we hope to provide policy-makers with a tool offering direction and focus for the work of significantly Improving the economic, political and social potential of all their citizens.In addition, we hope that this work provides the impetus for policy-makers to strengthen their commitment to the idea of women?s empowerment. Supporting Women's Empowerment Essay -- essays research papers Abstract Women empowerment is much talked about an issue by academicians, political thinkers and social scientists as regards to concepts like gender equality, financial independence, social inclusion, power etc. However there is a dire need of conceptual clarity of the term empowerment. This can be done by delineating it with the above overlapping concepts and suggesting inclusive approach towards enabling women themselves to critically review their own situation and participate in creating and shaping the society as agents of change themselves. Women themselves need to define the term empowerment which cannot be defined in terms of specific activities or end results because it involves a process whereby women can freely analyze, develop and voice their needs and interests, without them being pre-defined, or imposed from above. Masculinity Equality and Women?s Empowerment: There could be statistical evidence indicating improvements in indicators of gender equality, but unless the intervening process involved women as agents of that change, one cannot term it as empowerment. Gender equality or equity indicates the degree of equivalence in life outcomes for women and men, recognizing their different needs and interests and requiring a redistribution of power and resources. The women needs to build the conceptual framework of power for her and only then the concept of women empowerment and equality would hold relevance. This paper conceptualizes the issues of women empowerment through making her an agent of change for her own equivalence and studying the various domains where empowerment can be applied and discussed. 1. Economic participation 2. Economic opportunity 3. Political empowerment 4. Educational attainment .. ...olitical participation, and with relatively equal educational and economic opportunity and participation. Yet, as this study indicates, other countries show wide variation, lagging far behind in particular areas, some across all five dimensions. Aside from this general conclusion, and broad country comparisons, the data we have presented here shed light on the disparities within countries, in some cases either confirming formation gathered in other ways, or, in others, countering prevailing assumptions. By identifying and quantifying the gender gap, we hope to provide policy-makers with a tool offering direction and focus for the work of significantly Improving the economic, political and social potential of all their citizens.In addition, we hope that this work provides the impetus for policy-makers to strengthen their commitment to the idea of women?s empowerment.

An Alternative Approach – the Unfolding Model of Voluntary Employee Turnover

An alternative approach: The unfolding model of voluntary employee turnover Lee, Thomas W; Mitchell, Terence R Academy of Management. The Academy of Management Review; Jan 1994; 19, 1; ABI/INFORM Global pg. 51 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.